Method for preparing acethydrazide derivatives



The invention belongs to the technical field of chemical pharmacy, and particularly provides a novel method for preparing the acethydrazide derivatives having a structure of a general expression I. The method comprises the following steps of: performing a reaction of (R)-2-(2-chlorphenyl)-2-amido-methyl acetate and hydrazine hydrate, acetone and 3-pentanone to obtain an intermediate II; performing a reaction of the intermediate II and p-toluene sulfonic acid(2- thiophene ethanol)ester to obtain an intermediate III; and performing the cyclization reaction of the intermediate III to obtain an intermediate I. The method has the advantages of no splitting of products, simple process, short reaction time, high yield, high purity, little pollution and the contribution to the labor protection.




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