Novel aquagel tissue filling agent used for ophthalmonogy

新型眼科用水凝胶组织填充剂

Abstract

本发明涉及一种新型眼科用水凝胶组织填充剂及其制备方法,它是以单体N-乙烯基吡咯烷酮、甲基丙烯酸甲酯为原料,按质量配比N-乙烯基吡咯烷酮∶甲基丙烯酸甲酯=50~95%∶5~50%,进行共聚反应制备。水凝胶植入体在植入到眼部以后会在体液中的谷胱甘肽的作用下发生缓慢的降解反应,使体积溶胀度持续缓慢增加。本发明所述新型眼科用水凝胶组织填充剂具有较高的体积溶胀度和良好的抗压缩性能,在人眼中的耐受性和生物相容性好,可以自膨胀,在体液作用下缓慢降解,体积缓慢增大,可以减少植入初期由于植入体快速溶胀而产生的疼痛感。
The invention relates to a novel aquagel tissue filling agent used for ophthalmonogy and a preparation method thereof. The invention uses monomer N-vinyl pyrrolidone and methyl methacrylate as raw materials to carry out copolyreaction for preparation according to a certain mass mixture ratio of N-vinyl pyrrolidone/methyl methacrylate=50 to 95 percent/5 to 50 percent. After being implanted into eyes, aquagel implanting bodies generate slow degradation reaction under the effect of glutathione in body fluid, so the volume swelling capacity is continuously and slowly increased. The novel aquagel tissue filling agent used for ophthalmonogy of the invention has higher volume swelling capacity and good compression-resistance performance, has good tolerance and biocompatibility in human eyes, can realize the self expansion effect, and can slowly degrade under the effect of the body fluid, the volume is slowly increased, and the pain feeling caused by fast swelling of the implanted bodies in the early implanting stage can be reduced.

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Cited By (6)

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    CN-102319452-AJanuary 18, 2012天津大学用于眼科组织填充剂具有膨胀潜能的水凝胶及其制备方法
    CN-102344523-AFebruary 08, 2012金陵科技学院Preparation method of hydrogel for drug-loaded contact lens
    CN-102344523-BDecember 25, 2013金陵科技学院一种载药的角膜接触镜用水凝胶的制备方法
    CN-103304733-ASeptember 18, 2013复旦大学Preparation method of degradable environmental sensitive polymer nano hydrogel and application
    CN-103304733-BSeptember 28, 2016复旦大学一种可降解环境响应性聚合物纳米水凝胶的制备方法和应用
    CN-105542059-AMay 04, 2016深圳市昌华生物医学工程有限公司甲基丙烯酸甲酯、n-乙烯基吡咯烷酮共聚物的合成方法