Detection of mutations in a gene associated with resistance to viral infection, oas1

Détection de mutations dans un gène associées à la résistance à l'infection virale, oas1

Nachweis von Mutationen in einem mit der Resistenz gegenüber einer Virusinfektion assoziierten Gen, oas1

Abstract

A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.

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