7,9-Substituted tetracycline compounds

7, 9-substituierte Tetracyclin-Verbindungen

Composés de tétracycline substitués en position 7, 9

Abstract

A 7, 9-substituted tetracycline compound of Formula I: wherein: X is CH 2 ; R 4' and R 4" are each independently alkyl; R 4 is NR 4' R 4" ; R 2 , R 2' , R 3 , R 8 , R 10 , R 11 and R 12 are each hydrogen; R 5 is hydrogen or hydroxyl; R 7 is nitro; R 9 is alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyl, amino, arylalkenyl, arylalkynyl, thionitroso, acyl or-(CH 2 ) 0-3 NR 9c (=Z')ZR 9a ; Z is CR 9d R 9e , S, NR 9b or O; Z' is O, S or NR 9f ; and R 9a , R 9b , R 9c , R 9d , R 9e and R 9f are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic or heteroaromatic.

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