Funktionalisierte Nukleinsäuren und Partikel damit zur Behandlung von HIV-Infektionen

Acides nucléiques fonctionnalisés et particules les comportant pour le traitement des infections du VIH

Functionalized nucleic acids and particles comprising them for the treatment of HIV infections

Abstract

The present invention relates to a particle comprising a functionalized nucleic acid non-covalently associated to a cell-penetrating peptide, wherein: • the functionalized nucleic acid comprises, or consists of: - an HIV integrase-inhibiting oligonucleotide comprising from 11 to 20 contiguous nucleotides; and - at least one functionalizing group of the following formula (I) covalently linked to the oligonucleotide: • the cell-penetrating peptide comprises from 12 to 30 contiguous amino acids; • the particle is liable to be obtained by contacting the functionalized nucleic acid with the cell-penetrating peptide in a 1/5 to 1/15 molar ratio.

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