Anti-alpha2-integrin-antikörper und deren verwendungen

Anti-alpha2 integrin antibodies and their uses

Anticorps anti-integrine alpha-2 et leurs utilisations

Abstract

The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain of α2 integrin and inhibit the interaction of α2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treating α2β1-mediated disorders, including anti-α2 integrin antibodies that bind to α2 integrin without activating platelets.

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